Saturday, September 29, 2012

Journal of young Sir Arthur Conan Doyle published

The surgeon aboard the whaling vessel Hope was often covered in the blood of seals and other animals, his clothes frozen enough that he'd have to stand next to the ship's stove to thaw before undressing.

A first-time sailor, he wasn't supposed to take part in the clubbing of seals, but he did, and repeatedly fell into the frigid waters, nearly freezing to death.

A journal by the young man, written at age 20 in 1880, was published yesterday. ?The ?author? ?Sir Arthur Conan Doyle.

Best known for creating the ingenious detective Sherlock Holmes, Doyle was first a surgeon, and went along on the whaling ship after a friend of his backed out, according to a review of the book by the Daily Mail.

The journey was intense and bloody, and the sailors' job was to take as many seals and whales as possible. As noted by the Smithsonian, though, Doyle's journal of the trip isn't all blood and gore, and contains Doyle's neat prose and lovely illustrations of the ship and the terrain it explored in the Arctic Ocean. ?

The killing of whales was common at the time, although Doyle did write about his feelings of sympathy for the hunted animals. He also describes the beauty of the icy landscape and awe he felt upon seeing enormous humpback whales, which the sailors didn't hunt because they contained too little oil to make their capture worthwhile. Whale oil was valuable for its use in lamps, candle wax and other applications.

Doyle wrote about his experience in both fiction and nonfiction, which helped him first catch the eye of publishers. Although he completed medical school and briefly practiced as a surgeon, he soon realized his true talent lay in writing.

The account of his Arctic voyage is called "Dangerous Work: Diary of an Arctic Adventure" (British Library Publishing, 2012) and is available from the British Library Shop.

Reach Douglas Main at dmain@techmedianetwork.com. Follow him on Twitter @Douglas_Main. Follow OurAmazingPlanet on Twitter?@OAPlanet. We're also on?Facebook?and Google+.

Copyright 2012 OurAmazingPlanet, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://news.yahoo.com/whale-tale-sir-arthur-conan-doyles-arctic-adventure-134259633.html

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Biden Blames Bush Administration for Deficit

FORT MYERS, Fla. - Vice President Joe Biden placed the blame for the ballooning deficit on the Bush administration today, arguing that the previous administration saddled the country with the burden of trillions of dollars in debt.

"Let's get serious here! How did we get this debt? Ladies and gentlemen, they put two wars on a credit card. Not paying a penny, not paying a penny, even though I introduced legislation to pay for that war. They voted against it," Biden said at the Wa-Ke Hatchee Park Recreation Center. "Two, they voted for a new entitlement program without paying one penny for it, and that was clear. Number 3, they added another trillion dollars in the tax cut for the very wealthy, so what's the result? These are the facts, folks, these are the facts.

"The result was by the time the reins got turned back over to Barack [Obama] and me, they had doubled the national debt in eight years, doubled the national debt in eight years," Biden added.

Biden recounted that within the first week of being in office, Larry Summers, a top economic adviser to the president, warned newly inaugurated President Obama of the deficit the country faced.

"We were sitting in the oval office, and Larry Summers, the chief economic adviser, and the economic team came in and said 'Mr. President, looking at this year's budget you are going to have a trillion dollar deficit.' He said, 'I haven't done anything yet,'" Biden said. "I'm serious. They said, 'No, Mr. President, the budget they passed, the budget they passed in October of last year guarantees no matter what you do you're going to have a trillion dollar debt this year in the budget.' A trillion dollar deficit to be precise."

Earlier in the week, the Washington Post fact checked President Obama's claim that the Bush administration's policies accounted for 90 percent of the country's current deficit and rated the assertion as false, since the president also pushed spending increases and tax cuts that added to the deficit.

Biden also claimed the Obama administration has proposed a plan that would reduce the deficit by $4 trillion over 10 years and has already decreased the deficit by $1 trillion

"We've already reduced the deficit. In four years, we'll reduce it by another trillion dollars. Ladies and gentlemen look, there's an easy way to do this. We have to make some difficult decisions. We've made them, but we've got to ask the very wealthy to pay more," Biden said.

"President Obama and Vice President Biden have no credibility on reducing our national debt," Amanda Henneberg, a spokeswoman for Romney, responded in a statement. "Over the last four years, the Obama-Biden team has presided over the largest increase in the national debt of any administration in history. And President Obama's latest spending plan is riddled with accounting gimmicks and tax hikes, rather than policies that will get our long-term debt under control. Mitt Romney and Paul Ryan will take immediate steps to cut spending and put our nation on track toward a balanced budget."

Biden mocked the GOP's concern about the debt, saying, "I love how they bleed over the national debt," but adding that Republicans would be unwilling to sign onto a deficit reduction plan that would promise $10 in cuts in spending in exchange for a dollar increase in revenue.

The vice president honed in on energy, touting the Obama administration's work as well as highlighting what he believes is the GOP's misunderstanding the role conservation plays in energy exploration and expansion.

"I love to hear them talk about their energy policy, which is 'drill baby drill,' right? OK, now let me say something about drilling. You all realize that there are more gas and oil rigs working today, pumping today, than all the rest of the rigs in the entire rest of the world. Do you know that? That's a fact. That's why we're importing less than we have in decades, that's why we're in the position we're moving in," Biden said.

"Ladies and gentlemen, there is an exponential, exponential supply of natural gas done right and renewable energy that's here in this country," he said. "That's why we doubled - and they voted against it - and Romney talked against it, we doubled the fuel economy standards for cars and trucks by 2025. That will save 12 billion barrels of oil over the period of time. I don't know how they don't think conservation is part of this. They, they sure don't know it."

Also Read

Source: http://news.yahoo.com/biden-blames-bush-administration-deficit-184436550--abc-news-politics.html

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Friday, September 28, 2012

GRAPHIC PHOTOS ? Animals Being ?Starved To Death? In Vienna ...

Posted on: 2:13 pm, September 27, 2012, by Joe Millitzer, updated on: 04:53pm, September 27, 2012

VIENNA, MO (KTVI) ? Investigators say they have witnessed animals being ?starved to death? at a residence just north of Vienna on Highway 63. Maries County police were following up on a report of animal abuse when they say they found many animals without food or water.

Investigators applied for a search warrant and served it on the morning of September 27th. They found malnourished dogs, goats, pigs, cows, and horses. There were also at least six horse remains and numerous cow and pig remains.

Many of the animals have been seized by police and are in ?need of immediate medical attention?. A total of 40 animals have been seized.? More may be taken in protective custody at a later date.? Missouri State Animal Investigators, police and the Humane Society are from the Department of Agriculture are working on this case.

The owner of the property has not been charged at this time.? He may be facing numerous counts of animal neglect, and improper disposal of animal remains.? He is due in Maries County Associate court this Tuesday at 11am for an animal disposition hearing.? His name will not be released until criminal charges have been filed.

Source: http://fox2now.com/2012/09/27/graphic-photos-animals-being-starved-to-death-in-vienna-mo/

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News | Do You Want to Work Here? | Lehigh Valley Health Network

September 27th, 2012 by Matthew Burns

If you missed Lehigh Valley Health Network at the Allentown job fair sponsored by Pennsylvania CareerLink, don?t worry. You can still find plenty of opportunities to work for the health network on the careers section of our website, where you can browse all of the open positions and apply online. ?If you?re a registered nurse and want to work for a Magnet hospital, we?re looking for a number of critical care nurses. The health network offers competitive salaries and great benefits.

Source: http://www.lvhn.org/news/updates/do-you-want-to-work-here/252001

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Federal Housing Finance Agency Reports Mortgage Interest Rates ...

Washington, DC ? September 27, 2012 ? (RealEstateRama) ? The Federal Housing Finance Agency (FHFA) today reported that the National Average Contract Mortgage Rate for the Purchase of Previously Occupied Homes by Combined Lenders, used as an index in some adjustable-rate mortgage (ARM) contracts, was 3.56 percent based on loans closed in August. There was a decrease of 0.10 percent from the previous month. In March of 2012, FHFA began calculating interest rates using un-weighted survey data. The complete contract rate series can be found at http://www.fhfa.gov/Default.aspx?Page=251.

The average interest rate on conventional, 30-year, fixed-rate mortgage loans of $417,000 or less decreased 10 basis points to 3.74 in August. These rates are calculated from the FHFA?s Monthly Interest Rate Survey of purchase-money mortgages (see technical note). These results reflect loans closed during the August 27 ? 31 period. Typically, the interest rate is determined 30 to 45 days before the loan is closed. Thus, the reported rates depict market conditions prevailing in mid- to late-July.

The contract rate on the composite of all mortgage loans (fixed- and adjustable-rate) was 3.56 percent in August, down 9 basis points from 3.65 percent in July. The effective interest rate, which reflects the amortization of initial fees and charges, was 3.69 percent in August, down 9 basis points from 3.78 percent in July.

This report contains no data on adjustable-rate mortgages due to insufficient sample size.

Initial fees and charges were 1.07 percent of the loan balance in August, up 12 basis points from July. Eight percent of the purchase-money mortgage loans originated in August were ?no-point? mortgages, down 12 percent from the share in July. The average term was 27.5 years in August, unchanged from July. The average loan-to-price ratio in August was 75.8 percent, down 0.3 percent from 76.1 percent in July. The average loan amount was $256,900 in August, down $2,000 from $258,900 in July.

Recorded information on this index is available by calling (202) 649-3993. For technical questions on this index, please call David Roderer at (202) 649-3206. The September index value will be announced on Oct. 30, 2012.

Technical note: The data are based on a small monthly survey of mortgage lenders which may not be representative. Survey respondents are asked to report the terms and conditions on all conventional, single-family, fully amortized, purchase-money loans closed during the last five working days of the month. The sample is not a statistical sample but is rather a convenience sample. The data exclude FHA-insured and VA-guaranteed mortgages, refinancing loans, and balloon loans. This month?s data are based on 5,886 reported loans from 34 lenders, which may include savings associations, mortgage companies, commercial banks, and mutual savings banks. The effective interest rate includes the amortization of initial fees and charges over a 10-year period, which is the historical assumption of the average life of a mortgage loan.

###

The Federal Housing Finance Agency regulates Fannie Mae, Freddie Mac and the 12 Federal Home Loan Banks. These government-sponsored enterprises provide more than $5.7 trillion in funding for the U.S. mortgage markets and financial institutions.

Contact:
Corinne Russell (202) 649-3032
Stefanie Johnson (202) 649-3030

Tagged as: Mortgage Interest Rates, Reports

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    Washington, DC - August 28, 2012 - (RealEstateRama) -- The Federal Housing Finance Agency (FHFA) today reported that the National Average Contract Mortgage Rate for the Purchase of Previously Occupied Homes by Combined Lenders, used as an index in some adjustable-rate mortgage (ARM) contracts, was 3.66 percent based on loans closed in July. Beginning in March, FHFA is calculating interest...
  • Federal Housing Finance Agency Reports Mortgage Interest Rates
    Washington, DC - July 26, 2012 - (RealEstateRama) -- The Federal Housing Finance Agency (FHFA) today reported that the National Average Contract Mortgage Rate for the Purchase of Previously Occupied Homes by Combined Lenders, used as an index in some adjustable-rate mortgage (ARM) contracts, was 3.67 percent based on loans closed in June. Beginning in March, FHFA is calculating interest...
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Source: http://www.realestaterama.com/2012/09/27/federal-housing-finance-agency-reports-mortgage-interest-rates-11-ID017061.html

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Netanyahu asks U.N. to draw 'red line' on Iran's nuke plans (CNN)

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Thursday, September 27, 2012

The Dragons Are Coming! Watch the New Promo Trailer for ...

FOLLOWING ACCLAIMED RUNS IN AUSTRALIA, NEW ZEALAND

AND NORTH AMERICA

DREAMWORKS? HOW TO TRAIN YOUR DRAGON LIVE SPECTACULAR

ANNOUNCES NEXT LEG OF GLOBAL TOUR!

New York City area date, Izod Center, East Rutherford 9/27? 9/30

?Not only will it make you believe in dragons, you?ll believe a dragon can fly.?

? Pittsburgh Post-Gazette

?A visual and technical work of mind-boggling proportions.?

? Australian Stage

?A dazzling fusion of art and athleticism.?

? Entertainment Weekly

_____________________________________________________________

New York, NY? September 24, 2012 ??This summer, entertainment history was made as audiences across North America experienced the magic of fire-breathing dragons soaring through arena skies in DREAMWORKS? HOW TO TRAIN YOUR DRAGON LIVE SPECTACULAR.

Following a critically acclaimed launch in Australia and New Zealand, the US tour of DREAMWORKS? HOW TO TRAIN YOUR DRAGON LIVE SPECTACULAR has more dates on sale, following an engagement at the Izod Center, East Rutherford, NJ September 27 ? September 30.

Here are the new dates:? In 2012, Tacoma, WA (December 6?9), Fresno, CA (December 19?22), San Jose, CA (December 26?30), and in 2013, Sacramento, CA (January 3-6), Salt Lake City, UT (January 10-13) and Anaheim, CA (January 17-20).

Go to www.dreamworksdragonslive.com for on-sale dates and other ticket information.? Check back for additional tour markets in 2013 which will be announced soon.

Created by the studio that brought us blockbuster hits such as Shrek and Madagascar, The HOW TO TRAIN YOUR DRAGON LIVE SPECTACULAR was produced by the storytellers at DreamWorks Animation, and Global Creatures, the masterminds behind the international phenomenon Walking with Dinosaurs, the #1 grossing world tour of 2010. The tour is exclusively promoted by S2BN Entertainment.

Inspired by the hit movie How To Train Your Dragon, this live event is a never-before-seen production that audiences of all ages will never forget. HOW TO TRAIN YOUR DRAGON LIVE SPECTACULAR features more than a dozen dragons, some with wingspans of up to 46 feet, Viking warriors and world-class circus artists and acrobats combined with a heartwarming story that truly delivers a once-in-a-lifetime experience for the entire family.

Fire-breathing action, epic adventure and heartfelt laughter come together in a captivating story set in the mythical world of Vikings and wild dragons.? Based on the book by Cressida Cowell, it centers on Hiccup, a Viking teenager who doesn?t fit in with his tribe?s longstanding tradition of heroic dragon slayers.? Hiccup?s world is turned upside down when he encounters a dragon that challenges him and his fellow Vikings to see the world from an entirely different point of view.

?It is incredibly exciting to see our movie characters live on to thrill audiences in new entertainment experiences,? said Jeffrey Katzenberg, Chief Executive Officer of DreamWorks Animation. ?HOW TO TRAIN YOUR DRAGON LIVE SPECTACULAR is an extraordinary re-imagining of the story that breaks new ground in visual storytelling. The early reception to the show has been phenomenal, and we are now pleased to add more dates to bring HOW TO TRAIN YOUR DRAGON LIVE SPECTACULAR to even more audiences throughout America and Canada.?

Global Creatures Chief Executive Officer Carmen Pavlovic added, ?With DreamWorks we have forged a relationship with one of the world?s leading entertainment companies.?The collaboration fuses our own world-class technology with the vision and dedication of a company renowned for its cutting-edge creativity and storytelling skill.?We are excited to expand the boundaries of public expectation by creating a show that combines dynamic creatures, world class performers and incredible staging to not only thrill and intrigue, but to engage audiences on an emotional level as well.?

Michael Cohl is the founder and chairman of S2BN Entertainment, global promoter for HOW TO TRAIN YOUR DRAGON LIVE SPECTACULAR, and serves as lead producer of the Broadway?s smash hit Spider-Man: Turn Off the Dark. Cohl commented, ?HOW TO TRAIN YOUR DRAGON LIVE SPECTACULAR is the next logical step for me after Spider-Man: to be back in arenas where I?ve always been, and where the most exciting things happen. We are thrilled to be setting a new gold standard for live family entertainment while utilizing the full scope and scale of the arena floor and fly space. The show delivers cutting-edge production values which tell an incredible story and create an unforgettable and magical experience. This show will mesmerize children and parents alike.?

Sponsored by HP, HOW TO TRAIN YOUR DRAGON LIVE SPECTACULAR is brought to life through state-of-the-art technology unlike anything ever seen before in a live event experience.? Through DreamWorks Animation?s ongoing strategic relationship with HP, HP technology is part of the digital backbone for the production, providing family audiences across the globe with the most captivating live entertainment possible.

HOW TO TRAIN YOUR DRAGON LIVE SPECTACULAR breaks every rule of theatrical entertainment to fully immerse audiences into the show in ways that have not been attempted before. Barely contained within the arena, HOW TO TRAIN YOUR DRAGON LIVE SPECTACULAR utilizes the full venue, maximizing every dimension of the performance space to transport audiences into a mythical world of fire-breathing dragons who soar overhead at great speeds. The state-of-the-art animatronic technology and large-scale cinematic projections interact seamlessly with the live actors, who bring DreamWorks Animation?s heart-warming story to life through theatrical storytelling, martial arts and acrobatics.

Young Hollywood actor Riley Miner, an accomplished dancer and musical theater performer, will play the lead role of Hiccup. ?Joining Miner to share the role of Hiccup is Rarmian Newton, who won a Helpmann Award for his performance in the Australian production of Billy Elliot The Musical (2008).?? American stunt performer Gemma Nguyen, a third degree Black Belt and six-time world champion in Tae Kwon Do, plays Astrid.? Sharing the role of Astrid is Queenslander Sarah McCreanor who has starred in her own comedic productions and performed in a range of musicals and comedy shows.? Stalwart Australian actor Robert Morgan plays Stoick, Hiccup?s father and the rough and ready old-school chieftain of the brawny Viking tribe.? American Will Watkins will star as Gobber; French Kung Fu champion and stuntman Godefroy Ryckewaert plays Snotlout and Texan hip-hop dancer and rapper Dexter Mayfield will play Fishlegs. ?Australian hip-hop and break-dancer Virackhaly Ngeth has been cast as Ruffnut and Sydney break-dancer Frace Luke Mercado, a founding member of SKB (Street Kulture Breakers), as Tuffnut.

The cast of performers is assisted by an international technical team who has collectively created many of the world?s most memorable spectacles.? The team is led by award-winning director Nigel Jamieson, who won the 2011 Helpmann Award as Best Director for his production of Opera Australia?s La Fanciulla del West, as well as production designer Peter England and costume / projection designer Dan Potra.? The dragons themselves are created by Sonny Tilders and his team at The Creature Technology Company, whose work includes Walking With Dinosaurs ? the Arena Spectacular.? The cast of dragons pays homage to all of the favorites from the DreamWorks Animation film, including the single largest animatronic creature ever made by The Creature Technology Company. The stunning score features compositions from Icelandic singer-songwriter Jonsi from Sigur Ros and Oscar-nominated British film composer John Powell, who created the original score for the feature film.

HOW TO TRAIN YOUR DRAGON LIVE SPECTACULAR TOUR SCHEDULE

2012

September 20-23??????????????????? Buffalo, NY???????????????????????????? First Niagara Center

September 27-30??????????????????? East Rutherforld, NJ?????????????? Izod Center

October 4-7??????????????????????????? Albany, NY????????????????????????????? Times Union Center

October 11-14???? ?????????????????? Columbus, OH??????????????????????? Schottenstein Center

October 12-28 ?????????????????????? Milwaukee, WI?????????????????????? Bradley Center

November 1-4??????????????????????? Saskatoon, SK???????????????????????? Credit Union Centre

November 21-25??????????????????? Winnipeg, MB??????????????????????? MTS Centre

December 6-9???????????????????????? Tacoma, WA?????????????????????????? Tacoma Dome

December 20-23???????????????????? Fresno, CA????????????????????????????? Save Mart Center

December 26-30???????????????????? San Jose, CA?????????????????????????? HP Pavilion at San Jose

2013

January 3-6???????????????????????????? Sacramento, CA????????????????????? Powerbalance Pavilion

January 10-13???????????????????????? Salt Lake City, UT?????????????????? EnergySolutions Arena

January 17-20???????????????????????? Anaheim, CA????????????????????????? Honda Center

Visit:?www.dreamworksdragonslive.com

FOOTAGE and IMAGES available NOW at:

????????????https://dragons.sharefile.com/

HOW TO TRAIN YOUR DRAGON LIVE SPECTACULAR? 2012 DREAMWORKS ANIMATION LLC.

ALL RIGHTS RESERVED.

DREAMWORKS ANIMATION

DreamWorks Animation creates high-quality entertainment, including CG animated feature films, television specials and series, live entertainment properties and online virtual worlds, meant for audiences around the world.? DreamWorks Animation is the largest animation studio in the world and has released 23 animated feature films, which have enjoyed both critical and commercial successes. These include the franchise properties of Shrek, Madagascar, Kung Fu Panda and How to Train Your Dragon. DreamWorks Animation became the first studio to produce all of its feature films in 3D and in 2010 became the first Company to release three CG feature films in 3D in a single year.? The Company has been named one of the ?100 Best Companies to Work For? by FORTUNE? Magazine for four consecutive years. In 2012, DreamWorks Animation ranks #14 on the list.? DreamWorks Theatricals was established by DreamWorks Animation in 2007 to develop and produce live stage and arena show productions inspired by the Company?s franchise properties. DreamWorks Theatricals productions are guided by much of the creative leadership team that develops the studio?s award-winning feature films.

GLOBAL CREATURES

Global Creatures is an international entertainment group that develops new and exciting theatrical productions to take to audiences around the world.? The animatronics arm, The Creature Technology Company, invents and deploys the latest in animatronic design.? Their hugely successful production Walking with Dinosaurs ? The Arena Spectacular, based on the award winning BBC TV series, represents a new entertainment genre all on its own.? The production is a spectacle of unprecedented size and quality, which captivates young and old alike.? The Walking with Dinosaurs tour was the number one tour worldwide in 2010.? Global Creatures has announced King Kong ? Live on Stage, which will be produced in co-operation with the estate of ?Kong? creator Merian C. Cooper.? Global Creatures and Bazmark (the multi-media company founded and owned by Baz Luhrmann and Catherine Martin) have announced a partnership to produce a stage musical adaptation of the first movie of Baz Luhrmann?s ground-breaking Red Curtain Trilogy, Strictly Ballroom.

S2BN ENTERTAINMENT

S2BN is an entertainment company specializing in the production of family oriented shows for theatres and arenas.? Currently, S2BN has three successful shows in operation, the record breaking smash hit Spider-Man: Turn Off the Dark on Broadway, Rock of Ages now in its 4th year on Broadway, recently opened in London, touring throughout North America and on June 1st, 2012 a major Warner Brother Picture Release, and thirdly, Fuerza Bruta, also in its 5th year in New York and touring throughout the world.? For 30+ years S2BN?s leadership have been dominant and innovative forces in the international concert touring industry, working in exclusive partnerships with renowned, global artist such as The Rolling Stones, Barbra Streisand, U2 and Pink Floyd amongst many others.? In that time they have also created and/or promoted a wide range of unique family entertainment attractions in tennis, figure skating, motorsports, boxing and wrestling as well as theatre, opera and symphony.

RZO DRAGON PRODUCTIONS

The RZO Companies group was formed on July 1, 1988 through the merger of Sound Advice, Inc. and Joseph Rascoff & Company, Inc. by their principals William Zysblat and Joseph Rascoff, respectively. For over twenty-five years, RZO and its predecessor organizations have been actively involved in the music business as tour producers and full-service business managers. RZO has represented such illustrious music artists as Rolling Stones, David Bowie, Sting, U2, The Police, Luis Miguel, Patti LaBelle, David Byrne and many others.? The Company also represents personalities such as Carson Daly and Iman, along with the Estates of John Lennon and Ira and George Gershwin.

National press representative:

Boneau Bryan-Brown

Adrian Bryan-Brown, Joe Perrotta, Kelly Guiod ? 212-575-3030, jperrotta@bbbway.com, kguiod@bbbway.com

US Tour press representative:

Allied Integrated Marketing

Ginger Chan ? 323-330-8863, GChan@alliedim.com

Source: http://www.boneaubryanbrown.com/blog/2012/09/the-dragons-are-coming-watch-the-new-promo-trailer-for-dreamworks-how-to-train-your-dragon-live-spectacular-global-tour/

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?C?mon Honey, Bring Your Mortars, We?re Going To A Spontaneous Demonstration? (Powerlineblog)

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Tuesday, September 25, 2012

Appropriate sequencing of treatments among men with advanced ...

Whether a man is initially diagnosed with metastatic prostate cancer or progresses to have metastatic disease over time (after failure of standard first-line therapies), sooner or later they are all going to need ? in consultation with their doctors ? to decide on ?the best? way to manage their progressive disease through sequential or concurrent use of a number of recently approved agents (always assuming that cost and access are not determining factors). The problem is that ? at least at present ? there is no really appropriate way to determine what (if anything) is most likely to have the greatest effectiveness in an individual patient.

A case report published recently by Colbourn offers an excellent example of the complexities of this problem. Colbourn describes the following sequence of therapeutic interventions in a man of 58 years, initially diagnosed with an advanced form of prostate cancer in 2006:

  • Initial management with radical prostatectomy followed by androgen deprivation therapy (but his PSA continued to rise post-treatment).
  • Enrollment in a clinical trial of HE3235 for 6 months (but his disease subsequently progressed again).
  • Treatment with docetaxel-based chemotherapy for 4 months (followed by palliative radiation therapy).
  • Treatment with cabazitaxel-based chemotherapy, initiated in October 2010 (at which time his PSA level was > 5,400 ng/ml).

This sequence of treatments makes perfectly reasonable sense at a time when sipuleucel-T, abiraterone acetate, and enzalutamide were not approved therapeutic agents (although the patient may have been eligible for enrollment in the one or more clinical trials of abiraterone acetate or enzalutamide or other agents during this time frame).

What came next, however, was not exactly predictable:

  • The patient?s condition stabilized within weeks.
  • His PSA level demonstrated a progressive decline.
  • Continued cabazitaxel-based therapy allowed him to come off pain medications and to resume his normal activities.
  • As of January 2012, after 16 cycles of cabazitaxel, his PSA had declined by > 80 percent (to 994 ng/ml).

Colbourn further reports that the patient tolerated cabazitaxel well; needed only occasional dosing with myeloid growth factors for management of neutropenia; and experienced only mild diarrhea.

Why did this man respond so well to cabazitaxel, after relatively rapid failure in response to other forms of therapy? How can we optimize the likelihood that other such men could be identified with accuracy, such that cabazitaxel could be administered early? Is it possible that this man, if treated with cabazitaxel immediately after his radical prostatectomy, might have shown an even better response to treatment?

These are the sorts of questions that we need to be able to answer if we are going to be able to truly individualize treatment in the most appropriate manner for men with clinically significant prostate cancer. And, as we bring more products through clinical trials and make them available for the treatment of progressive prostate cancer, the pressure to be able to know who is most likely to respond best to specific combinations of drugs (or just individual drugs as in this case study) is only going to increase.

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Source: http://prostatecancerinfolink.net/2012/09/25/appropriate-sequencing-of-treatments-among-men-with-advanced-prostate-cancer/

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NFL Week 4 Giants @ Eagles

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Source: http://www.sportsviews.com/bet/19735/NFL_Week_4__Giants___Eagles

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Scientists Discover Why You Remember Good News But Ignore the Bad [Science]

Humans tend to remember good news and attenuate the bad: our brains filter the two, and make us remember positive things more strongly than negative. It's a standard human trait—and now scientists understand how it happens. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/Bbvh0n9gP_E/scientists-discover-why-you-remember-good-news-but-ignore-the-bad

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Monday, September 24, 2012

Tips On How To Get An Inexpensive Web Hosting Prepare | Tourism ...

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Make sure you refer to Absolutely Free Domain Name And Hosting ? Most Excellent Alternative For Low Price Range Websites Operator, since the guide will provide you with additional information on the issue.

Source: http://www.tourismarticles.org/country-tourism/netherlands/tips-on-how-to-get-an-inexpensive-web-hosting-prepare-6.html

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Oregon Ducks football: Face it -- Colt Lyerla can line up anywhere (video)

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Sunday, September 23, 2012

Verizon iPhone's secret feature: It's 'unlocked'

Featured

1 day

Apple iPhone 5

If you didn't stay up until 3 a.m. to pre-order an iPhone 5 last week, you were probably?too late to get one confirmed for shipment by Frida... Read more

1 hr.

The Verizon Wireless version of the iPhone 5, which went on sale Friday, comes with a secret and unexpected feature: it works on AT&T's network as well.

Confirming blog reports, The Associated Press found that a Verizon iPhone 5 accepts an AT&T "SIM card" ? a chip that identifies a phone to a network. The phone can then be active on AT&T's network.

It's the first time Verizon iPhones have been able to access AT&T's network without complicated hacking procedures. The feature gives Verizon customers the option to switch carriers rather than renewing an expired contract.

It's unclear whether the feature is intended and whether the phones will work with other carriers such as T-Mobile USA.

Verizon Wireless referred questions about the SIM card feature to Apple, which did not respond.?

??Reporting by Peter Svensson, AP

Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://www.nbcnews.com/technology/gadgetbox/verizon-iphones-secret-feature-its-unlocked-1B6047331

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ADVERTISEMENT FOR BIDS Kawaihau Sports Villa- Association of Apartment Owners, Owner c/o Certified Hawaii, AAMC? 4-1579 Kuhio Hwy., Suite 102-A, Kapaa, HI 96746, Address Separate sealed Bids for the construction of: Install 22 new septic tanks and

ADVERTISEMENT FOR BIDS

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c/o Certified Hawaii, AAMC? 4-1579 Kuhio Hwy., Suite 102-A,
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September 21 & 23, 2012)

Source: http://kauai-www2.kauaiworld.com/mobile-classified/ads/29043893/?market=admarket

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Saturday, September 15, 2012

NCAA Football (American) O... H!!

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Pay Per Click Advertising Do You Know What Your Missing ...

Article by Antoine

Pay Per Click Advertising Do You Know What Your Missing ? Advertising ? Online Advertising

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With ppc you only pay for the actual click through to your web site or campaign. Some Inexpensive Pay per click internet advertising lists your web site according to your bid for a certain search keyword unlike adwords. PPC internet advertising can be a very affordable cost in comparison to other manner of marketing on the Internet. You don?t pay any amount until a visitor actually clicks on your listing to go t see your web site. The low cost ppc internet advertising counts how many visitors click on your listing and takes the money out of an account you have set up with them.Another advantage is the simplicity of the pay-per-clickprocess. You just bid and you?re up and running. It doesn?tdemand any specific technical knowledge, though the moreyou know about search engines and keywords, the easier -and more effective ? the process will be.

The downside is that pay-per-click is essentially a biddingwar. A higher bid than yours will lower your position onsearch engine results. This means that you will have toraise your bid to regain your position ? which canobviously become quite expensive, especially if you arebidding on a popular keyword.

You host the images to be used in your pay per click internet advertising, so you can monitor and change the campaign at anytime. Targeted advertising in pay for clicks will help increase the amount of customers you obtain at a controlled add spend.There are many low cost pay per click internet advertising solutions available in the internet. All you have to make sure is that the advertising alternative guarantees your satisfaction and your web site grows in traffic and converts into sales.In determining good quality and affordable ppc advertising service, make sure to perform very carefully thought out and structured add campaigns in order to boost your conversion and traffic to your web site.Everyday millions of people around the world click on Pay-Per Click Advertising Campaign. With the booming internet industry and the ever growing online business, an ad of virtually anybody on the planet can be seen on the internet anywhere in the world. After you finish running your first campaign study and analyzing your business,do your research to produce the most appropriate keywords for your business. For a successful pay per click to work you should identify what keywords convert on your landing pages. If needed, changes are suggested to construct the perfect landing page or keyword campaign which would work for an entry point to your website.

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If you are asking what is pay per click advertising. It is one great way to increase the visibility of your new web site. It is the fastest growing marketing tool there is today. Because of a wide range of companies servicing inexpensive pay per click advertising, you must be careful to choose which company to trust.

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If you are asking what is pay per click advertising. It is one great way to increase the visibility of your new web site. It is the fastest growing marketing tool there is today. Because of a wide range of companies servicing inexpensive pay per click advertising, you must be careful to choose which company to trust.












Use and distribution of this article is subject to our Publisher Guidelines
whereby the original author?s information and copyright must be included.

Source: http://freereleasepress.com/pay-per-click-advertising-do-you-know-what-your-missing/

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Wal-Mart India stores coming due to landmark agreement ?

NEW DELHI ? India agreed Friday to open its huge market to foreign retailers such as Wal-Mart in a surprising decision that was part of a flurry of economic reforms aimed at sparking new growth in the country?s sputtering economy.

The Cabinet?s decision ? after a similar proposal was withdrawn under withering criticism last year ? immediately generated optimism that a government plagued by scandal was finally breaking out of the political paralysis that had stifled reforms for months.

?This is a landmark decision in India?s economic reforms process,? said Rajan Bharti Mittal, whose retail company, Bharti Enterprises, has a joint venture with Wal-Mart.

Prime Minister Manmohan Singh said the reforms were made to spur economic growth and to attract foreign investment.

??I believe that these steps will help strengthen our growth process and generate employment in these difficult times,? he wrote on his Twitter account, appealing for public support.

However, political opponents and even some allies, decried the decision to allow in international supermarket chains, saying it would hurt small retailers and farmers.

?(It) will lead to job losses for millions of our people,? D. Raja, a Communist Party lawmaker, told the NDTV news channel.

The Cabinet also agreed to allow foreign investment in airlines and to sell stakes in state-owned companies. On Thursday, the government decided to reduce fuel subsidies and allow the price of diesel to rise, a move hailed by the business community but criticized by political allies and opponents.

The decision on retail investment Friday would allow foreign firms to own a majority stake in multi-brand retailers here for the first time. However, individual states would have the right to decide whether to let the retailers operate from their territory.

States led by the ruling Congress party would be most likely to allow them, meaning the big cities of New Delhi and Mumbai would have new shopping options.

U.S.-based Wal-Mart, British-based Tesco PLC, French-based retailer Carrefour and others have been interested in entering India, a country of 1.2 billion people where retail is the second-biggest industry behind agriculture.

Commerce Minister Anand Sharma said India badly needed the infrastructure investment that would come from these firms. Currently, about 35 to 40 percent of produce rots before it gets to the stores, he said.

Under the Cabinet decision, at least 50 percent of the foreign investment would have to be in back-end infrastructure, such as processing, distribution and storage.

??It will generate large numbers of jobs in rural India for our men and women,? Sharma said.

The government said farmers would benefit because less of their produce would rot, small retailers would become more competitive and efficient and consumers will get lower prices and better quality. The policy would also bring in badly needed inflows of investment and foreign currency.

The government had agreed on the same proposal last year but then withdrew that decision because of protests from coalition partners, a capitulation that badly damaged its credibility with international investors.

Since then, economic growth has fallen, with business leaders and analysts blaming the government?s inability to make needed reforms.

Kunal Ghosh, a spokesman for government ally Trinamool Congress, said his party continued to oppose the plan but would not say whether it would withdraw support from the coalition.

The government relaxed rules on foreign investment in the broadcast industry and in power exchanges, which provides a platform for companies to buy and sell power.

The government also agreed to sell minority stakes in its oil, copper and aluminum companies as well as its Metals and Minerals Trading Corporation.

The main opposition Bharatiya Janata Party criticized the surprise decisions.

??We consider it as a betrayal of the country, betrayal of the Parliament by this government,? said Balbir Punj, of the BJP.

The government?s decision on airline investment would allow foreign airlines to own up to 49 percent of an Indian airline. India?s airline industry has expanded enormously in recent years, but only one airline has been able to turn a consistent profit. The government-owned Air India and the private Kingfisher have both suffered from labor strife and financial problems.

Aviation Minister Ajit Singh said the decision ??sends a very clear message to a sector that has been under stress.?

But it was not clear if any foreign airlines would be interested in buying a minority interest in some of India?s most struggling airlines.

The government also made a key change to its decision earlier this year to allow foreign retailers selling only a single brand to own 100 percent of their stores, a decision largely seen as aimed at bringing furniture retailer IKEA to India.

The previous decision forced the company to source 30 percent of their products from small cottage industries. Now, it can source that 30 percent from any Indian industry.

Source: http://www.masslive.com/business/index.ssf/2012/09/wal-mart_india_stores_coming_due_to_landmark_agreement.html

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Friday, September 14, 2012

LG Optimus L9 saunters through FCC, asks for a Martini

LG Optimus L9 saunters through FCC, asks for martini afterward

LG's latest L-series smartphone, the Optimus L9, has just breezed (elegantly) through the FCC's radio frequency trial-by-screwdriver. The dinner-jacket-white clad Android smartphone is part of the "L-Style design philosophy" from the Korean maker, which emphasizes budget panache over brute performance. As such, it's a handsome but plasticky device, with a 4.7-inch IPS screen, ICS, qtranslator language app, dual-core 1GHz CPU, 1GB of RAM, 2,150mAh battery and 5-megapixel shooter. Vodafone in Europe showed the price as €340 unsubsidized or €50 on contract, but a member of the L-series family has yet to cross the pond. However, a surprise peek of its Optimus L7 sibling as US Cellular's upcoming Splendor shows there's some hope for a stateside cameo.

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LG Optimus L9 saunters through FCC, asks for a Martini originally appeared on Engadget on Fri, 14 Sep 2012 05:38:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2012/09/14/lg-optimus-l9-saunters-through-fcc/

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Nintendo says Wii U will launch on Nov. 18

(AP) ? Nintendo's upcoming Wii U gaming console will start at $300 and go on sale in the U.S. on Nov. 18, in time for the holidays, the company said Thursday.

A "deluxe" version will sell for $350. It will be black instead of white and include extra features such as more memory, a charging stand and the game "Nintendo Land."

Nintendo Co. has been trying to drum up excitement for the Wii U, which is the first major gaming console to launch since 2006. The device has a touch-screen controller called the Wii U GamePad. It also plays games made for the original Wii.

Nintendo said the latest game in its wildly popular Mario franchise, "New Super Mario Bros. U," will be available when the new console launches. It will include new ways to play that use the GamePad. It will also offer new challenges for advanced Mario players, such as trying to complete a level without touching the ground. "Mario" and other classic games have long been Nintendo's main draw.

The company also announced new entertainment features for the console. Called "Nintendo TVii," the service collects all the ways users have to watch movies, TV shows and sports. This includes pay-TV accounts along with services such as Hulu and Netflix. The GamePad works as a fancy remote controller and will let viewers browse shows they can watch.

TVii "brings all of your services to one place," said Reggie Fils-Aime, president and chief operating officer of Nintendo of America.

So if you like the TV show "Modern Family," for example, it will pull in the show's episodes from every available source.

The service also captures scenes from live TV and displays them on the controller. Viewers can then comment on the scenes and share that on Twitter or Facebook if they want. With this feature, Nintendo is playing into what many people already do while they watch TV ? comment and share things with friends using a second screen such as a smartphone.

TVii will be available Nov. 18 as well, at no extra cost.

Among the games available on the Wii U will be Activision Blizzard Inc.'s "Call of Duty Black Ops II." The "Call of Duty" games have been holiday best-sellers for the past several years.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/495d344a0d10421e9baa8ee77029cfbd/Article_2012-09-13-Nintendo-Wii%20U/id-20e095f8104948b79d8abad73c429628

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Who made the anti-Muslim video? What L.A. County knows but is not saying.

After being contacted by the FBI and State Department, L.A. County has blocked public access to the permit that was issued to shoot at least part of the anti-Muslim film. Permits name a film's writer, director, and producer, among others.

By Gloria Goodale,?Staff writer / September 13, 2012

A Yemeni protester, (c.), destroys an American flag pulled down as other hold a banner in Arabic that reads, "any one but you God's prophet" at the US Embassy compound during a protest about a film ridiculing Islam's Prophet Muhammad, in Sanaa, Yemen, Thursday. Dozens of protesters gathered in front of the US Embassy in Sanaa to protest against the American film "The Innocence of Muslims" deemed blasphemous and Islamophobic.

Hani Mohammed/AP

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A?movie cannot?shoot in L.A. County without a permit, and a permit makes public the names of the film?s writer, director, and producer.

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This means that answers to the question of who was behind ?Innocence of Muslims,? the?anti-Muslim project that sparked a wave of mob violence across the Middle East and may have created the cover for a deadly attack on US diplomats in Libya, now appear to be in the hands of?Los Angeles County officials. And they are not talking.

A US law enforcement official told the Associated Press Thursday that authorities believe that a 55-year-old Coptic Christian, a US citizen named Nakoula Basseley Nakoula,?is behind the film. A convicted felon, Mr. Nakoula has changed his version of events numerous times in interviews with various news outlets.

On Thursday, after being contacted by both the FBI and?the US State Department and on its legal counsel?s advice, the office of the CEO of L.A. County removed from public?availability what has been confirmed as the permit issued to shoot at least part of the anti-Muslim film. Permits are normally available online and by request from the county.

?This was done to give us time to make sure that we are not putting anyone in danger,? says Ryan Alsop,?assistant?CEO?of L.A. County, adding, ?we have up to 10 days to respond to any request, and we are just making sure that we don?t?endanger public safety.?

Paul Audley, president of FilmL.A., the nonprofit charged with issuing film permits for L.A. County, confirms that a permit was issued to Media for Christ, a conservative nonprofit based in Duarte, Calif., east of Pasadena, to shoot what eventually became ?Innocence for Muslims.?

The permit was pulled for a project titled ?Desert Warriors,? he says, but is quick to add, ?We do not get involved with the content of a movie because that would get into issues of free speech.?

It was a single day permit ? for Aug. 18, 2011 ? and is filed with Los Angeles County under permit number F00043012.

The filming took place at the Blue Cloud Movie Ranch in Santa Clarita valley, just north of Los Angeles, according to Mr. Audley.

Calls to Media for Christ on Wednesday and Thursday received denials of any involvement. A woman who identified herself as Diana said Wednesday ?we had nothing to do with the film.?

She acknowledged, however, that Steve Klein, an insurance agent and talk show host who appears every Thursday for an hour on its broadcasting outlet, hosting ?Wake Up, America,? was a ?consultant on the project.?

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/yAJDp0mIBuc/Who-made-the-anti-Muslim-video-What-L.A.-County-knows-but-is-not-saying

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